Treatment with Small Molecule Inhibitor

Treatment with Small Molecule Inhibitor (JAK inhibitor or JAKinibs)

If you have rheumatoid arthritis (RA), your doctor may suggest Janus kinase (JAK) inhibitors to help ease your joint pain and swelling. These drugs tamp down your overactive immune system — the body’s defense against germs — to help prevent damage to your joints.
JAK inhibitors belong to a family of medicine called DMARDs (disease-modifying antirheumatic drugs). Two JAK inhibitors, baricitinib (Olumiant) and tofacitinib (Xeljanz), are approved by the FDA to treat rheumatoid arthritis. More should appear in the next few years if they succeed in clinical trials.